The AusCP-CTN will conduct RCTs of current interventions (Botulinum toxin A); phase II trials of new interventions and/or methods of delivery (telerehabilitation) with clinical/ imaging biomarkers to identify and monitor brain structure and functions that underpin response to treatments.

The CRE team will build on their strong track records in undertaking RCTs of interventions for infants/children with CP and their families to commence world class trials. CRE members have undertaken many of the largest RCTs internationally in upper limb rehabilitation, prevention of hip displacement, pharmacology to reduce spasticity and early interventions (developmental care for infants born <30 weeks). Our strong track records in epidemiological studies and population-based cohort studies will enable development of international trials. Our links to the CP registers will enable us to test the changes in outcomes for children with CP identified earlier, who received neuroprotectants and earlier brain based rehabilitation.


Current phase II clinical trials and RCTs in this theme:

  • Botulinum toxin-A on muscle structure/function in children with CP.
  • Preventing Adverse Outcomes of Neoantal Hypoxic Ischaemic Encephalopathy with Erythropoeitin: A Randomised Controlled Multicentre Australian Trial. (PAEAN Trial)
  • Neuroprotective role of sulphate among preterm babies. (SuPreme)
  • Randomised trial Rehabilitation EArly for Congenital Hemiplegia (REACH)
  • RCT Goal-directed Motor Enrichment for infants at risk of CP. (GAME)
  • RCT of a parenting program for parents of very preterm infants. (Prem Baby Triple P)
  • Parenting Acceptance and Commitment Therapy (PACT): a trial of an innovative web-based intervention for parents of children with cerebral palsy. (PACT)


Current clinical and population based longitudinal studies in this theme:

  • Comprehensive surveillance to PREDICT outcomes for children with CP. (PREDICT-CP)
  • A motivational physiotherapy program to facilitate participation in physical activities for kids with cerebral palsy (ParticiPAte CP)