National Health and Medical Research Council

REACH: Randomised trial Rehabilitation EArly for Congenital Hemiplegia

Chief Investigarors: CIs Boyd, Ziviani, Novak, Badawi, Elliott; AI Sakzewski.

Funding: NHMRC1078877 (2015-8) $938k.

Aims: To examine the efficacy of modified CIMT compared to an equal dose of traditional bimanual training (BIM) on early reaching and grasping and brain (re)organisation in 150 infants with asymmetric brain lesions who are at high risk of developing hemiplegia. Infants will be identified on neonatal ultrasound or MRI in a multisite

Randomised Controlled Trial (RCT): A total sample size of 150 (75 in each group) allows a difference ≥0.5 SD with α=0.05 and 80% power to be detected with 15% loss to f/u. Interventions: Both interventions commence at 3 months C.A. with a graduated intensity of training up until 12 months (total 84 hours), delivered at home by the parent supported by a paediatric OT/PT with Telehealth support.

Update: Recruitment has commenced in 4 states.

New knowledge: First RCT comparing two very early rehabilitation approaches for infant hemiplegia.


Project members

Professor Roslyn Boyd

Scientific Director, Queensland Cerebral Palsy and Rehabilitation Research Centre
Child Health Research Centre, The University of Queensland

Professor Jenny Ziviani

Professor in Occupational Therapy
School of Health and Rehabilitation Sciences, The University of Queensland

Professor Iona Novak

Head of Research, Cerebral Palsy Alliance Research Institute
School of Medicine, The University of Sydney

Professor Nadia Badawi

Macquarie Group Foundation Chair of Cerebral Palsy
Cerebral Palsy Alliance.
Neonatologist, Medical Director
Grace Centre for Newborn Care, Westmead

Professor Catherine Elliott

Chair of Allied Health, Child and Adolescent Health Service, School of Occupational Therapy and Social Work
Curtin University

A/Prof. Leanne Sakzewski

Senior Research Fellow
Child Health Research Centre, University of Queensland