Our focus for earlier detection of CP using neurological and clinical biomarkers in preterm and term born infants has expanded to detecting Neurodevelopmental disability (NDD), in Indigenous infants and CALD populations. Our preterm cohort (PREBO) has tested 272 infants at 30 and 40 weeks post menstrual age (PMA) with GMs, clinical correlates and neuroimaging (white/grey matter injury, diffusion, connectomes) with electroencephalography (EEG) markers for mild, moderate or severe CP. While MRI and EEG are available in tertiary centres, we have also identified clinical bedside tools that correlate with early brain injury. We are testing a KT package for physicians (AI McNamara, CIs Novak, Boyd).
Current Projects in this theme:
- PREBO: Prediction of PREterm Brain Outcomes
- NEBO: Neonatal Encephalopathy Brain Outcomes
- Application of MOS in infants who have congenital anomalies requiring surgery
- Early Moves (sub-study of Origins Cohort)
- LEAP Prospective Cohort study: Early detection of Aboriginal & Torres Strait Islander infants at high risk of adverse motor and cognitive outcomes at 12 months CA.
- Non-invasive movement sensing for early identification of NDD
- Developing novel blood based diagnostics for brain injury
Past studies in this theme:
- Early prediction of typical outcome and mild developmental delay for prioritisation of service delivery for very preterm and very low birthweight infants (PREMTiME)