PREBO

Chief Investigators: Colditz P, Boyd R, Malhotra A, Rose S, Boashash B, Ditchfield M, Fahey M, Pannek K, Moldrich R.

Funding: NHMRC Project grant (2015-2019) $1,645,141

Rationale: Prematurity is the cause of ≈40% CP; and 10-15% of infants born <30wks will develop CP, however most are not diagnosed until 12-24 months, limiting access to early intervention. The PREBO study is an extension of the PPREMO study conducted in Queensland.

Design: Prospective cohort study of 300 preterm infants and 40 healthy, term controls.

Aims: To examine the relationship between brain structure on MRI and function (General Movements, neurological/neurobehavioral) at 30 and 40 weeks post menstrual age (PMA), to predict neuromotor outcome at 12 wks C.A. and 24 months (Bayley III).

Update: We have undertaken earlier MRI at 30 and 40 weeks PMA in n=120/300 preterm infants to determine the best combination of clinical, imaging and EEG markers for early detection of mild, moderate or severe CP.

New knowledge: Preliminary findings have shown relationships between bedside clinical tools and MRI markers of WMI at 30 weeks PMA. Very early markers that correspond with developing CP will enable earlier referral to intervention and enable measurement of the effects of earlier interventions.

Project weblink at the Perinatal Research Centre, UQ

Project weblink at the Queensland Cerebral Palsy and Rehabilitation Research Centre, UQ