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Study short name Basic Eligibility Criteria Locations that are/will be recruiting Clinical trial information link
PREBO

PRETERM GROUP
Infants born at less than 31 weeks gestational age
English speaking family
Live within 200km of either the Royal Brisbane and Women's Hospital or Monash Medical Centre
Have no congenital or chromosomal abnormality that would impact their development

TERM REFERENCE GROUP
Infants born between 38 and 41 weeks postmenstrual age
English speaking family
Live within 200km of either the Royal Brisbane and Women's Hospital or Monash Medical Centre
Have no congenital or chromosomal abnormality that would impact their development
QLD, VIC ANZCTR
PREMTiME

Infants born at less than 1500g or less than 32 weeks gestation who are admitted to the the Special Care Nursery at Nambour Hospital.

QLD ANZCTR
PAEAN trial (Phase III)

Up to 23hr old

≥35 weeks gestation

1+ indicator of perinatal depression

moderate to severe encephalopathy

hypothermia initiated by 6hr of age

ACT, NSW, QLD, SA, TAS, VIC, WA, NZ

clinicaltrials.gov

ANZCTR

Botulinum toxin-A on muscle structure/function in children with CP.

Confirmed diagnosis of unilateral or bilateral spastic type CP with a predominant spastic motor type and more involvement of the lower limb.

Aged 2-5 years at study entry.

Gross Motor Functional Classification System (GMFCS) classification of I-II, independently ambulant.

Prescribed intramuscular BoNT-A injection to the lower leg for spasticity treatment

QLD, WA, VIC ANZCTR
SuPreme Preterm infants <32 weeks' gestation QLD  
REACH

3-6 months old (corrected age) AND have one or more of the following identified between 3-6 months c.a:

1. Asymmetric brain lesion identified on cranial ultrasound or MRI including asymmetric (one sided or more involved on one side) or unilateral brain injury including preterm or term arterial stroke, grade III or IV intraventricular haemorrhage, periventricular leukomalacia or asymmetric deep gray matter (DGM) lesions; AND/OR

2. Absent Fidgety Movements on General Movements Assessment at 12 weeks C.A. AND/OR

3. Reduced upper limb function with asymmetric reach/grasp.

NSW, QLD, VIC, WA ANZCTR
GAME Aged 12-26 weeks corrected for prematurity;
Discharged home from hospital; and
Diagnosis of cerebral palsy OR diagnosis of “high risk of cerebral palsy” via:
(i) General Movements “Absent fidgety” score + abnormal brain MRI/CUS indicating cerebral palsy; OR (ii) General Movements “Absent fidgety” score + Hammersmith Infant Neurological Evaluation score <57@ 12-weeks / <59 @ 26-weeks of age; OR (iii) Abnormal brain MRI/CUS indicating cerebral palsy + Hammersmith Infant Neurological Evaluation score <57@ 12-weeks / <59@ 26-weeks of age
NSW, VIC, QLD ANZCTR
PACT Parents of children aged 2-10 years with CP. As PACT uses integrated web-based delivery parents are required to have: (1) reliable internet access at home (e.g. ADSL) and be committed to maintaining internet access for the duration of the study; (2) a mobile phone for receiving text messages; (3) an email address for receiving emails; and (4) access to Skype. Australia ANZCTR
Predict-CP Follow-up at 8 to 11 years of preschool age cohorts of children with Cerebral Palsy that were examined from 2 to 5 years as part of two previous overlapping, longitudinal studies (NHMRC 465128; NHMRC 569605, ACTRN 1261200169820). QLD ANZCTR
ParticiPAte

Children aged 8-12 years with a diagnosis of CP

GMFCS I-III, confirmed by the Child’s Paediatrician, Rehabilitation Physician, or Neurologist

Resides within 200km radius of Brisbane

Each included child’s primary caregiver is also a participant
QLD ANZCTR
Cluster RCT to improve translation of intensive UL rehabilitation for children with Unilateral CP. Occupational therapists across four geographical regions, working with children with cerebral palsy QLD ANZCTR