Ganaxolone (GNX): A new treatment for neonatal seizures

Chief Investigators: T Yawno, CI Fahey.

Funding: CP Alliance Project (2015-2018) $250,000.

Aims: We have successfully treated seizures following Hypoxic Ischemic Injury with Ganaxolone in the lamb. Trials continue to determine whether GNX confers superior neuroprotection to phenobarbitone. Infants whom have neonatal seizures have a high risk of developing CP.

New knowledge: This trial will inform the influence of neonatal seizures on brain damage. If successful it will shift the way newborn seizures are treated and will rapidly evolve to clinical trial.