Hot Topics in Cerebral Palsy - Muscle Research Forum

Friday 30th November 2018
Centre for Children's Health Research, Brisbane

Join us for a day of presentations from a panel of national and international experts, on the topics of muscle and biomechanical research in cerebral palsy.

Professor Richard L. Lieber, PhD.

International Keynote Speaker
Professor Richard L. Lieber, PhD.
Professor & Chief Scientific Officer, Shirley Ryan Ability Lab & Departments of Physical Medicine & Rehabilitation & Biomedical Engineering. Northwestern University, Chicago. 

Topic: Biological & Biomechanical Studies of Skeletal Muscle Contractures in Cerebral Palsy.
Skeletal muscle is a highly plastic tissue, responding both to level of use and amount of neural input.  After cerebral palsy (CP) altered neural input can result in muscle contractures.  We have studied the mechanics and biology of muscle from children with wrist flexion contractures secondary to CP. Dramatic architectural changes are observed in these children whereby sarcomere lengths are dramatically altered relative to patients without upper motor neuron lesions.  This suggests dramatic alterations in the regulation of muscle growth in these children.  Biomechanical studies of isolated single muscle cells reveal an increased passive modulus and decreased resting sarcomere length suggesting alterations in the cellular cytoskeleton.  Gene expression profiling reveals a number of “conflicting” biological pathways in spastic muscle. Specifically, this muscle adapts by altering processes related to extracellular matrix production, fiber type determination, fiber hypertrophy and myogenesis.  These transcriptional adaptations are not characteristic of muscle adaptations observed in Duchenne muscular dystrophy or limb immobilization.  Superimposed upon the dramatic biological & structural adaptations is a loss in the number of satellite cells that are located throughout the muscle.  Even the remaining satellite cells have epigenetic changes that can dramatically influence our ability to rehabilitate these muscles.  Recent data shows that several anti-cancer drugs are able to reverse these epigenetic changes, thus “rescuing” the satellite cells and promoting myogenesis.  Taken together, these results support the notion that, while contracture formation is multifactorial and neural in origin, significant structural alterations in muscle also occur.  An understanding of the specific changes that occur in the muscle and extracellular matrix may facilitate the development of new conservative or surgical therapies for this devastating problem.

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Cost

The cost of this event is inclusive of morning tea, lunch, and afternoon tea, and is discounted for students and QPRS staff.

  • Standard: $100
  • Students/QPRS: $50
Registration

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3. Once you have made payment, please forward your payment confirmation email to auscpnetwork@uq.edu.au to confirm your registration.

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Hot Topics in Cerebral Palsy - Muscle Research Forum

Fri 30 Nov 2018 9:00am5:00pm
Registration: 
21 September 201830 November 2018
Forum registration fee (inclusive of morning tea, lunch, and afternoon tea):
Standard: $100
Students/QPRS: $50

Contacts

Australasian Cerebral Palsy Clinical Trials Network (AusCP-CTN)